Blog

Levitra Plus: An In-depth Review

Characteristic Details
Active Ingredient Vardenafil
Available Dosages 5mg, 10mg, 20mg
Formulation Tablet
Onset of Action 30-60 minutes
Duration of Action Up to 5 hours
More Information

Pharmacokinetics

Levitra Plus, known for its vardenafil component, exhibits a distinct pharmacokinetic profile. Upon oral administration, absorption is swift. Peak plasma concentration occurs within one hour. Food intake, especially high-fat meals, can delay this peak. However, its bioavailability remains unaffected. Metabolism primarily involves hepatic cytochrome P450 isoform 3A4. Excretion occurs predominantly through fecal matter, with a smaller proportion via urine.

The drug demonstrates a terminal half-life of approximately 4-5 hours. This duration allows for a satisfactory therapeutic window for sexual activity. Consistency in the pharmacokinetic parameters contributes to its predictable efficacy and safety profile. Dosing adjustments might be necessary for individuals with hepatic impairments. In such cases, a reduced dosage of vardenafil 5mg is advisable.

Other Uses for Levitra Plus

While primarily indicated for erectile dysfunction, Levitra Plus might serve other purposes. Off-label uses include treatment for premature ejaculation. Studies have highlighted its potential in enhancing ejaculatory latency. However, clinical evidence remains limited. Patients should seek medical advice before considering this use.

Further research explores its application in pulmonary arterial hypertension. Its mechanism, similar to sildenafil, involves vasodilation. This effect may alleviate symptoms of hypertension, although this is not an officially approved indication. Other investigational uses may arise as pharmacological understanding deepens.

Levitra Plus Contraindications

Levitra Plus poses contraindications, especially for those with cardiovascular conditions. Patients with a history of myocardial infarction or stroke should exercise caution. Nitrates and vardenafil combinations can result in significant hypotension.

Allergy to vardenafil or any component necessitates avoidance. Further contraindications include severe hepatic impairment and end-stage renal disease. Those with retinitis pigmentosa should refrain from usage due to potential visual disturbances.

Levitra Plus Interactions

Numerous drug interactions involve Levitra Plus. Concomitant use with nitrates presents significant risks. Additionally, alpha-blockers may exacerbate hypotensive effects. Caution is essential when combining vardenafil 20mg with antihypertensives.

Patients should also be wary of CYP3A4 inhibitors. Drugs like ketoconazole can elevate vardenafil plasma levels. This interaction necessitates dosage adjustments. It is prudent to disclose all medications to a healthcare provider.

Effects of Levitra Plus

The primary therapeutic effect of Levitra Plus is erectile facilitation. Vardenafil enhances nitric oxide effects, leading to vasodilation. This process improves blood flow to the penile tissue, facilitating erection. The outcome hinges on sexual stimulation.

Adverse effects can manifest. Common ones include headache, flushing, and rhinitis. Visual disturbances, though rare, may occur. In some cases, prolonged erections or priapism demand immediate medical intervention.

Where to Buy Levitra Plus Online

Purchasing Levitra Plus online is convenient, but vigilance is crucial. Verified pharmacies ensure genuine products. Look for licensed platforms with positive reviews. Always prioritize safety over cost.

Avoid unauthorized vendors to prevent counterfeit risks. Engage in thorough research to find reliable sources. It is advisable to consult healthcare professionals for guidance on reputable sites.

Dosage Strength Form
Levitra Plus 5mg 5mg Tablet
Levitra Plus 10mg 10mg Tablet
Levitra Plus 20mg 20mg Tablet
  • Seek professional guidance before starting any medication.
  • Always purchase from verified sources to ensure quality.
  • Monitor for adverse reactions and report them promptly.
  • Adhere to prescribed dosages for optimal results.

Primary source:

Leave a Reply